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Veys KR, DHauwers KW, van Dongen A, Janssen MC, Besouw MTP, Goossens E, van den Heuvel LP, Wetzels A, Levtchenko EN (2018) First successful conception induced by a male cystinosis patient

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doi: 10.3389/fonc.2025.1557638 Received 08 January 2025 Accepted 04 March 2025 Published 26 March 2025 Volume 15 - 2025 Edited by Egidio Iorio, National Institute of Health (ISS), Italy Reviewed by Johann Matschke, Essen University Hospital, Germany Vahur Valvere, North Estonia Medical Centre, Estonia Updates Copyright 2025 Hernndez-Esquivel, Del Mazo-Monsalvo, Pacheco-Velzquez, Feregrino-Mondragn, Robledo-Cadena, Snchez-Thomas, Jasso-Chvez, Saavedra and Marn-Hernndez

We will dissect the most significant of these translational failuresincluding the inefficacy of IL-23 pathway inhibition, the dual effects of IL-17 blockade (effective in joints but potentially worsening intestinal inflammation)[9, 10], and the persistent challenges of microbiome-targeted therapies such as probiotics and fecal microbiota transplantation (FMT)[11]to argue that a new, more nuanced therapeutic paradigm is required